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No distinct dose adjustment suggested when tofacitinib coadministered with strong CYP2C19 inhibitors; decrease tofacitinib dose if coadministered with both of those moderate CYP3A4 and strong CYP2C19 inhibitors .crizotinib improves levels of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. Dose reduction may ve